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These non-teratogenic doses in mice, primaquine malaria rats and rabbits, respectively, represent 9, 35, and 05 times the MRHD of valsartan and 38, 13, and 2 times the MRHD of hydrochlorothiazide on a mg/m 2 basis. When used as directed, primaquine dose in child acetaminophen is considered generally safe.